Comparative analysis of the exosomal contents of DF-1 cells infected by ALV-J

Exploration of the abnormal expression exosomal molecules during infection avian leukosis virus subgroup J (ALV-J) is essential to provide a deeper understanding exosome’s role in viral pathogenesis involved. The study aimed investigate differentially expressed proteins and miRNAs exosomes derived from DF-1 cells infected by ALV-J, their gene function involved signal pathways. We isolated ALV-J. were determined proteomics transcription detection technology. A Gene Ontology (GO) analysis Kyoto Encyclopedia Genes Genomes (KEGG) pathway identified target genes pathways regulated different or/and miRNAs. total 116 (58 upregulated 58 downregulated) 3 (all upregulated) determined. These 155 pathways, which highest number cancer was (up to) seven. Both Ribosome ECM-receptor interaction pathway. results suggested that ALV-J changed significantly.